Protective effects of renal denervation based on MRI assessment of the brain in patients with resistant hypertension

Abstract Purpose The purpose of this single-centre, prospective, comparative study was to evaluate the pattern and severity brain structural changes in patients with resistant hypertension based on MRI assessments their one year after renal denervation. Material methods comprised 58 (RH), aged 52.1±9.1 years, who underwent denervation (RDN) according good clinical practice guidelines. Patients office blood pressure measurements, 24-hour monitoring (BPM), scanning. Using MRI, cerebrospinal fluid (CSF) system particular linear measurements cerebral lateral ventricles, external subarachnoid spaces 6 regions (in right left frontal, parietal, occipital lobes), sizes 3rd 4th ventricles (length width), dimensions intracerebral cisterns (quadrigeminal, prepontine, chiasmatic), presence periventricular leukoaraiosis focal white matter were evaluated. Results Initially, RH had a high incidence alterations: 75% fine lesions, impaired CSF dynamics, 23% sulcal widening, 90% oedema. After RDN, significant hypotensive effect noted. According number without dynamics did not change significantly: 25% initially, 20% later (χ2=0.63 p=0.43, χ2=0.72 p=0.40). grade I months significantly increased 12 from 50% 64% (χ2=4.00, p=0.046) due lowering II (χ2=1.56, p=0.21). widening decreased: 8% following RDN (χ2=40.21 p=0.000). oedema procedure; however, lesions decreased (from 75 60%, p=0.02). Conclusion Thus, it has been revealed that are characterised by alterations assessments. A bilateral denervation, there improvement intracranial signs decrease parameters (Table 1). Figure 1 shows example intervention. Funding Acknowledgement Type funding sources: None.